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Başlık: Hemostatic effect of a chitosan linear polymer (Celox (R)) in a severe femoral artery bleeding rat model under hypothermia or warfarin therapy
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Acil Tıp Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/İstatistik Anabilim Dalı.
0000-0003-2271-5659
Köksal, Özlem
Özdemir, Fatma
Çametöz, Betül
İşbil Büyükcoşkun, Naciye
Sığırlı, Deniz
AAK-8332-2020
AAH-1692-2021
AAA-7472-2021
23389880200
7006765911
57215331517
55665951400
24482063400
Anahtar kelimeler: Emergency medicine
Bleeding control
Celox (R)
Hypothermia
Warfarin
N-acetyl glucosamine
Lethal groin injury
Lingual hemostasis
Swine model
Topical hemostats
Animal-model
Hemorrhage
Trauma
Survival
Agents
Yayın Tarihi: 2011
Yayıncı: Ulusal Travma ve Acil Cerrahi Derneği
Atıf: Köksal, Ö. vd. (2011). "Hemostatic effect of a chitosan linear polymer (Celox (R)) in a severe femoral artery bleeding rat model under hypothermia or warfarin therapy". Ulusal Travma ve Acil Cerrahi Dergisi, 17(3), 199-204.
Özet: In this study, the hemostatic efficacy of Celox (R) in rats under hypothermia or warfarin treatment was investigated. A total of forty-eight Sprague-Dawley female rats weighing 200-350 g were used in the study. Six experimental study groups were designed, as follows: Group 1: Normothermia + compression; Group 2: normothermia + Celox (R); Group 3: hypothermia + compression; Group 4: hypothermia + Celox (R); Group 5: normothermia + warfarin + compression; and Group 6: normothermia + warfarin + Celox (R). Celox (R) provided effective hemorrhage control in all three tested groups. There was a statistically significant difference between compression and Celox (R) implementation in all groups in terms of hemostasis (p-values for the normothermia, hypothermia and warfarin groups were p < 0.05, p < 0.01 and p < 0.01, respectively). Furthermore, the compression numbers were significantly lower in all of the groups that received Celox (R) than in those in which compression alone was applied (p-values for the normothermia, hypothermia and warfarin groups were p < 0.01, p < 0.01 and p < 0.001, respectively). Celox (R) provides effective hemorrhage control under conditions of normothermia, hypothermia and use of the oral anticoagulant agent warfarin.
URI: https://doi.org/10.5505/tjtes.2011.88155
https://jag.journalagent.com/travma/pdfs/UTD-88155-RESEARCH_ARTICLE-KOKSAL.pdf
http://hdl.handle.net/11452/23287
ISSN: 1306-696X
Koleksiyonlarda Görünür:Scopus
TrDizin
Web of Science

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