Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/25463
Title: Tetraiodothyroacetic acid (Tetrac) and nanoparticulate tetrac arrest growth of medullary carcinoma of the thyroid
Authors: Dyskin, Evgeny
Lansing, Lawrence S.
Bharali, Dhruba Jyoti
Mousa, Shaymaa S.
Bridoux, Alexandre
Hercbergs, Aleck A.
Lin, Hungyung
Davis, Faith B.
Glinsky, Gennadi Victor
Glinskii, Anna B.
Ma, J.
Davis, Paul J.
Mousa, S. A.
Uludağ Üniversitesi/Veterinerlik Fakültesi/Temel Bilimler Bölümü.
0000-0002-5600-8162
Yalçın, Murat
AAG-6956-2021
57192959734
Keywords: Activated protein-kinase
Cell-surface receptor
Alpha-catenin
Proangiogenic action
Microarray analysis
Gamma-catenin
E-cadherin
Hormone
Expression
Integrin
Endocrinology & metabolism
Animalia
Mus musculus
Issue Date: Apr-2010
Publisher: Endocrine
Citation: Yalçın, M. vd. (2010). "Tetraiodothyroacetic acid (Tetrac) and nanoparticulate tetrac arrest growth of medullary carcinoma of the thyroid". Journal of Clinical Endocrinology and Metabolism, 95(4), 1972-1980.
Abstract: Context: Tetraiodothyroacetic acid (tetrac) blocks angiogenic and tumor cell proliferation actions of thyroid hormone initiated at the cell surface hormone receptor on integrin alpha v beta 3. Tetrac also inhibits angiogenesis initiated by vascular endothelial growth factor and basic fibroblast growth factor. Objective: We tested antiangiogenic and antiproliferative efficacy of tetrac and tetrac nanoparticles (tetrac NP) against human medullary thyroid carcinoma (h-MTC) implants in the chick chorioallantoic membrane (CAM) and h-MTC xenografts in the nude mouse. Design: h-MTCcells were implanted in the CAM model (n = 8 per group); effects of tetrac and tetrac NP at 1 mu g/CAM were determined on tumor angiogenesis and tumor growth after 8 d. h-MTC cells were also implanted sc in nude mice (n = 6 animals per group), and actions on established tumor growth of unmodified tetrac and tetrac NP ip were determined. Results: In the CAM, tetrac and tetrac NP inhibited tumor growth and tumor-associated angiogenesis. In the nude mouse xenograft model, established 450-500 mm(3) h-MTC tumors were reduced in size over 21 d by both tetrac formulations to less than the initial cell mass (100 mm(3)). Tumor tissue hemoglobin content of xenografts decreased by 66% over the course of administration of each drug. RNA microarray and quantitative real-time PCR of tumor cell mRNAs revealed that both tetrac formulations significantly induced antiangiogenic thrombospondin 1 and apoptosis activator gene expression. Conclusions: Acting via a cell surface receptor, tetrac and tetrac NP inhibit growth of h-MTC cells and associated angiogenesis in CAM and mouse xenograft models.
URI: https://doi.org/10.1210/jc.2009-1926
https://academic.oup.com/jcem/article/95/4/1972/2597596?login=true
http://hdl.handle.net/11452/25463
ISSN: 0021-972X
1945-7197
Appears in Collections:Scopus
Web of Science

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