Please use this identifier to cite or link to this item:
http://hdl.handle.net/11452/28977
Title: | The peri-microvascular edema in hippocampal CA1 area in a rat model of sepsis |
Authors: | Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Bölümü. 0000-0003-3368-8123 Kafa, İlker Mustafa Arı, İlknur Kurt, Mustafa Ayberk AAG-7125-2021 AAR-4341-2020 8450193200 8450193100 35603735000 |
Keywords: | Septic encephalopathy CA1 Fecal peritonitis Hippocampus Peri-microvascular edema Septic encephalopathy Brain Lipopolysaccharide Pathogenesis Inflammation Activation Responses |
Issue Date: | Jul-2007 |
Publisher: | Wiley |
Citation: | Kafa, İ. M. vd. (2007). "The peri-microvascular edema in hippocampal CA1 area in a rat model of sepsis". Neuropathology, 27(3), 213-220. |
Abstract: | Encephalopathy is a common complication of sepsis. However, little is known about the morphological changes that occur in the brain during sepsis. In this study, fecal peritonitis was induced in Wistar rats, which had been monitored for 4 h before their brains were removed and samples from the CA1 area taken. In addition to higher blood pressure with a decreasing pattern and a significant drop in rectal temperature, an increased heart rate and marked respiratory failure were observed. The tissue was investigated and compared with corresponding hippocampal samples taken from sham-operated and not operated control groups. Significantly more peri-microvascular edema was found in the hippocampal CA1 area in the septic group. The percentages of the peri-microvascular edema were 158.57 +/- 3.6%, 122.84 +/- 1.5% and 120.24 +/- 1.9% in the fecal peritonitis group, sham-operated and not operated control groups, respectively. The results may suggest that the edema observed around the microvessels may participate in the pathogenesis of the septic encephalopathy probably by causing in the microvascular permeability characteristics. |
URI: | https://doi.org/10.1111/j.1440-1789.2007.00757.x https://onlinelibrary.wiley.com/doi/10.1111/j.1440-1789.2007.00757.x http://hdl.handle.net/11452/28977 |
ISSN: | 1440-1789 0919-6544 |
Appears in Collections: | PubMed Scopus Web of Science |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.