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Başlık: Sublethal toxicity of esbiothrin relationship with total antioxidant status and in vivo genotoxicity assessment in fish (Cyprinus carpio L., 1758) using the micronucleus test and comet assay
Yazarlar: Selvi, Mahmut
Benli, A. Çağlan Karasu
Memmi, Burcu Koçak
Dinçel, Aylin Sepici
Sarıkaya, Rabia
Erkoç, Figen Ünlü
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.
0000-0003-1620-1918
0000-0002-7687-3284
0000-0002-3595-6286
Çavaş, Tolga
Vatan, Özgür
Çinkılıç, Nilüfer
Yılmaz, Dilek
Zorlu, Tolga
AAH-3508-2021
O-7508-2015
AAH-5296-2021
6602989548
16235098100
26533892300
6701369462
36629756000
Anahtar kelimeler: Environmental sciences & ecology
Toxicology
Water resources
Esbiothrin
Genotoxicity
Micronucleus test
Comet assay
Total antioxidant status
Fish
Carp
Induced oxidative stress
Channa-punctata bloch
Dna-damage
Peripheral erythrocytes
Pyrethroid insecticides
Mosquito repellents
Liza-saliens
Water fish
Responses
Capacity
Coprosma kauensis
Cyprinidae
Cyprinus carpio
Hexapoda
Pisces
Antioxidants
Blood
Toxicity
Carp
Comet assay
Cyprinus carpio
Esbiothrin
Fish
Genotoxicity
Micronucleus test
Total antioxidant status
Comet assays
Esbiothrin
Micronucleus test
Total antioxidant status
Antioxidant
Aquatic ecosystem
Blood
Concentration (composition)
Cyprinid
Database
Dose-response relationship
Ecotoxicology
Genotoxicity
Insecticide
Nontarget organism
Pollution exposure
Sublethal effect
Toxicity test
Fish
Yayın Tarihi: Kas-2013
Yayıncı: Wiley
Atıf: Selvi, M. vd. (2013). "Sublethal toxicity of esbiothrin relationship with total antioxidant status and in vivo genotoxicity assessment in fish (Cyprinus carpio L., 1758) using the micronucleus test and comet assay". Environmental Toxicology, 28(11), 644-651.
Özet: Esbiothrin, synthetic pyrethroid with quick activity against insects, is widely used against household pests and in public health. Despite widespread use, data on ecotoxicity and genotoxic effects are extremely scarce. The aim of the present study is to evaluate the genotoxic potential of esbiothrin on a model fish species Cyprinus carpio L., 1758 (Pisces: Cyprinidae, koi) using the micronucleus test and comet assay in peripheral blood erythrocytes. Effects of two sublethal exposure concentrations on plasma total antioxidant status (TAS mmol/L), and Hct values were examined. On the basis of the 96 h LC50 data from U.S. EPA ecotox database (32 g/L) two sublethal exposure concentrations (5 and 10 g/L) were used together with ethyl methanesulfonate (EMS) (5 mg/L) as positive control. Five fish were used for each dose/duration group (24, 48, and 72 h) under controlled laboratory conditions. The fish showed behavioral changes at the higher dose. Plasma TAS (mmol/L) levels decreased in 24 h; an increase was observed slightly for 48 and obviously for 72 h in both exposure doses. Similarly, hematocrit (Hct) values differed between exposure duration but no significant differences in mean values were found between groups of the same exposure time. The general trend was a rise after 48 h, which decreased afterwards. Our results revealed significant increases in the frequencies of micronuclei and levels of DNA strand breaks and thus demonstrated the genotoxic potential of this pesticide on fish, a nontarget organism of the aquatic ecosystem. To our knowledge this is the first study to report observable genotoxic effects of esbiothrin on fish.
URI: https://doi.org/10.1002/tox.20760
https://onlinelibrary.wiley.com/doi/10.1002/tox.20760
http://hdl.handle.net/11452/29123
ISSN: 1520-4081
1522-7278
Koleksiyonlarda Görünür:Scopus
Web of Science

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