Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29807
Title: Catheter-directed therapy in acute pulmonary embolism with right ventricular dysfunction: A promising modality to provide early hemodynamic recovery
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
0000-0002-9027-1132
0000-0002-6375-1472
0000-0003-3604-8826
0000-0003-0297-846X
Dilektaşlı, Aslı Görek
Çetinoğlu, Ezgi Demirdoğen
Acet, Nilüfer Aylin
Erdoğan, Cüneyt
Ursavaş, Ahmet
Özkaya, Güven
Coşkun, Funda
Karadağ, Mehmet
Ege, Ercüment
AAG-8744-2021
Z-1424-2019
AAD-1271-2019
A-4421-2016
AAI-3169-2021
36466376600
57189524206
56507253300
8293835700
8329319900
16316866500
21734137500
6601970351
6701341320
Keywords: Research & experimental medicine
Mechanical thrombolysis
Pulmonary embolism
Thrombolytic therapy
Rheolytic thrombectomy
Management
Fragmentation
Thrombolysis
Fibrinolysis
Embolectomy
Outcomes
Patient
Issue Date: 15-Apr-2016
Publisher: Int Scientific Information
Citation: Dilektaşlı, A. G. vd. (2016). "Catheter-directed therapy in acute pulmonary embolism with right ventricular dysfunction: A promising modality to provide early hemodynamic recovery". Medical Science Monitor, 22, 1265-1273.
Abstract: Background: Catheter-directed therapy (CDT) for pulmonary embolism (PE) is considered as an alternative to systemic thrombolysis (ST) in patients with hemodynamically unstable acute PE who are considered at high bleeding risk for ST. We aimed to evaluate the efficacy and safety of CDT in the management of acute PE with right ventricular dysfunction (RVD). The primary outcomes were mortality, clinical success, and complications. Secondary outcomes were change in hemodynamic parameters in the first 24 hours following the procedure. Material/Methods: Medical records of consecutive patients diagnosed as having acute massive or submassive PE with accompanying RVD treated by immediate CDT at our institution from January 2007 to January 2014 were reviewed. Patient characteristics, mortality, achievement of clinical success, and minor and major bleeding complications were analyzed in the overall study group, as well as massive vs. submassive PE subgroups. Change in hemodynamic parameters in the second, eighth, and 24th hours after the CDT procedure were also analyzed. Results: The study included 15 consecutive patients (M/F=10/5) with a mean age of 54.2 +/- 16.6 years who underwent immediate CDT. Nine of the patients had submassive PE, and 6 had massive PE. In-hospital mortality rate was 13.3% (95% CI, 0.04-0.38). One major, but not life-threatening, bleeding episode was evident in the whole group. Hemodynamic parameters were stabilized and clinical success was achieved in 14/15 (93.3%; 95% CI, 70.2-98.8) of the patients in the first 24 hours. Notably, the hemodynamic recovery was significantly evident in the first 8 hours after the procedure. Conclusions: CDT is a promising treatment option for patients with acute PE with RVD with no fatal bleeding complication. In experienced centers, CDT should be considered as a first-line treatment for patients with acute PE and RVD and contraindications for ST, with the advantage of providing early hemodynamic recovery.
URI: https://doi.org/10.12659/MSM.897617
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835153/
https://medscimonit.com/abstract/index/idArt/897617
http://hdl.handle.net/11452/29807
ISSN: 1643-3750
Appears in Collections:Scopus
Web of Science

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.