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Başlık: Bioinspired scaffold induced regeneration of neural tissue
Yazarlar: Altun, Esra
Aydoğdu, Mehmet O.
Sengil, Ahmet Z.
Ekren, Nazmi
Haskoylu, Merve E.
Oner, Ebru T.
Altuncu, Nese A.
Oztürk, Gürkan
Crabbe-Mann, Maryam
Ahmed, Jubair
Gündüz, Oğuzhan
Edirisinghe, Mohan
Bursa Uludağ Üniversitesi/Ziraat Fakültesi/Gıda Mühendisliği Bölümü.
Togay, Sine O.
AAC-6337-2021
36468917400
Anahtar kelimeler: Bacterial cellulose
Polymer science
Polycaprolactone
Electrospinning
Nerve regeneration
Biomimetic
Peripheral-nerve regeneration
Poly-epsilon-caprolactone
Bacterial cellulose
Nanofibrous scaffolsds
Electrospun nanofibers
Stems-cells
Fabrication
Biocompatibility
Biomaterials
Composites
Biocompatibility
Biomimetics
Cell adhesion
Cell culture
Cells
Cellulose
Electrospinning
Nanofibers
Polycaprolactone
Polymer blends
Scaffolds (biology)
Tissue
Bacterial cellulose
Dorsal root ganglia (DRG)
Extracellular matrices
Murine fibroblasts
Nanofibrous scaffolds
Nerve regeneration
Nerve tissue engineering
Primary cell cultures
Tissue regeneration
Yayın Tarihi: 5-Şub-2019
Yayıncı: Pergamon-Elsevier Science
Atıf: Altun, E. vd. (2019). ''Bioinspired scaffold induced regeneration of neural tissue''. European Polymer Journal, 114, 98-108.
Özet: In the last decade, nerve tissue engineering has attracted much attention due to the incapability of self-regeneration. Nerve tissue regeneration is mainly based on scaffold induced nanofibrous structures using both bio and synthetic polymers. The produced nanofibrous scaffolds have to be similar to the natural extracellular matrix and should provide an appropriate environment for cells to attach onto. Nanofibrous scaffolds can support or regenerate cells of tissue. Electrospinning is an ideal method for producing the nanofibrous scaffolds. In this study, Bacterial cellulose (BC)/Poly (epsilon-caprolactone) (PCL) blend nanofibrous scaffolds were successfully prepared by electrospinning for nerve tissue induced repair. The produced nanofibrous scaffolds contain well defined interconnected nanofiber networks with hollow micro/nanobeads. Firstly, in-vitro biocompatibilities of nanofibrous scaffolds were tested with L2929 murine fibroblasts and improved cell adhesion and proliferation was observed with polymer blends compared with PCL only. The primary cell culture was performed with dorsal root ganglia (DRG) cells on nanofibrous samples and the samples were found suitable for enhancing neural growth and neurite outgrowth. Based on these results, the BC/PCL (50:50 wt.%) nanofibrous scaffolds exhibited nerve-like branching and are excellent candidate for potential biomimetic applications in nerve tissue engineering regeneration.
URI: https://doi.org/10.1016/j.eurpolymj.2019.02.008
https://www.sciencedirect.com/science/article/pii/S0014305718324765
http://hdl.handle.net/11452/30623
ISSN: 0014-3057
1873-1945
Koleksiyonlarda Görünür:Scopus
Web of Science

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