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Başlık: Study description and baseline characteristics of the population enrolled in a multinational, observational study of teriparatide in postmenopausal women with osteoporosis: the Asia and Latin America Fracture Observational Study (ALAFOS)
Yazarlar: Chen, Chung-Hwan
Elsalmawy, Abdulaziz H.
Ish-Shalom, Sophia
Lim, Seung-Jae
Ai-Ali, Nadia S.
Cunha-Borges, Joao L.
Yang, Huilin
Casas, Noemi
Altan, Lale
Moll, Thomas
Gurbuz, Sirel
Brnabic, Alan J. M.
Burge, Russel T.
Marin, Fernando
Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri/Fizik Tedavi ve Rehabilitasyon Bölümü.
Altan, Lale
AAH-1652-2021
6603281363
Anahtar kelimeler: General & internal medicine
Research & experimental medicine
Fractures
Observational study
Osteoporosis
Teriparatide
Questionnaire-physical function
Parathyroıd-hormone 1-34
Quality-of-life
Opaq-pf
Prevention
Guidelines
Yayın Tarihi: 3-Haz-2019
Yayıncı: Taylor
Atıf: Chen, C.H. vd. (2019). ''Study description and baseline characteristics of the population enrolled in a multinational, observational study of teriparatide in postmenopausal women with osteoporosis: the Asia and Latin America Fracture Observational Study (ALAFOS)''. Current Medical Research and Opinion, 35(6), 1041-1049.
Özet: Objective: To describe the study design and baseline patient characteristics of the Asia and Latin America Fracture Observational Study (ALAFOS) to better understand the profile of patients receiving teriparatide during the course of routine clinical practice in Asia, Latin America, the Middle East and Russia. Methods: Prospective, observational, non-interventional study in postmenopausal women with osteoporosis who are prescribed teriparatide for up to 24 months, according to local medical standards, with a 12 month post-treatment follow-up. Measures: Demographics, risk factors for osteoporosis and fractures, history of fracture, prior osteoporosis medications, comorbidities, physical function, back pain and quality of life (QoL). Results: In total 3031 postmenopausal women (mean age 72.5 years) recruited at 152 sites in 20 countries were analyzed; 62.9% had a history of fragility fracture after age 40 (33.0% of patients with spinal, 14.2% with hip fractures). The mean (SD) bone mineral density T-scores at baseline were -3.06 (1.40) and -2.60 (1.05) at the lumbar spine and femoral neck, respectively. At entry, 43.7% of patients were naive to prior osteoporosis treatments; 40.5% of patients reported >= 1 fall in the past year. The median (Q1; Q3) EuroQoL Visual Analog Scale (EQ-VAS) for perceived overall health status was 60 (50; 80). The mean (SD) worst back pain Numeric Rating Scale in the last 24 hours was 4.6 (3.3). Conclusions: Our data indicates that patients who were prescribed teriparatide in the ALAFOS participant countries had severe osteoporosis, high prevalence of fractures, disabling back pain and poor QoL. The frequency of patients receiving prior osteoporosis medications was lower than in previous observational studies conducted in other locations.
URI: https://doi.org/10.1080/03007995.2018.1552576
https://www.tandfonline.com/doi/full/10.1080/03007995.2018.1552576
http://hdl.handle.net/11452/33016
ISSN: 0300-7995
1473-4877
Koleksiyonlarda Görünür:Scopus
Web of Science

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