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Başlık: Impaired cognitive performance and hippocampal atrophy in Parkinson disease
Yazarlar: Yıldız, Demet
Tufan, Fatih
Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.
0000-0002-2274-3230
0000-0002-3425-0740
0000-0001-5229-0001
Erer, Sevda
Zarifoglu, Mehmet
Hakyemez, Bahattin
Bakar, Mustafa
Karlı, Necdet
Varlıbaş, Zeynep Nigar
DVY-9744-2022
EHN-5825-2022
AAI-2318-2021
EKN-8251-2022
JDE-9380-2023
EDI-1148-2022
25635370800
6603411305
6602527239
26643051200
6506587942
36515788700
Anahtar kelimeler: General & Internal medicine
Parkinson disease
Minimal cognitive impairment
Neuropsychological tests
Cognitive functions
Hippocampal volume
Progressive supranuclear palsy
Alzheimers-disease
Lewy bodies
Brain atrophy
Cerebral atrophy
Dementia
MRI
Decline
Rates
Conversion
Yayın Tarihi: 2015
Yayıncı: TÜBİTAK
Atıf: Yıldız, D. vd. (2015). "Impaired cognitive performance and hippocampal atrophy in Parkinson disease". Turkish Journal of Medical Sciences, 45(5), Special Issue, 1173-1177.
Özet: Background/aim: Dementia is common in Parkinson disease (PD). Since magnetic resonance imaging has been used, hippocampal atrophy has been shown in PD patients with or without dementia. In this study we sought the correlation of cognitive decline with bilateral hippocampal volume in PD patients. Materials and methods: Thirty-three patients with diagnosis of idiopathic PD and 16 healthy subjects were included in this study. PD patients were divided into two groups as normal cognitive function and mild cognitive impairment (MCI). The Mini-Mental State Examination and detailed cognitive assessment tests were performed for all patients for cognitive analyses. Depression was excluded by the Geriatric Depression Scale. Results: The mean onset age of disease was 55 years for PD patients without dementia and 59 for PD patients with MCI. According to the Hoehn-Yahr scales, 24% of patients had grade 1, 58% had grade 2, and 18% had grade 3 disease. Right and left hippocampal volumes decreased along with cognitive test scores in PD patients. Increased right hippocampal volume was correlated with forward number test in the MCI-PD group. Conclusion: These findings suggest that memory deficit is associated with hippocampal atrophy in PD patients.
URI: https://doi.org/10.3906/sag-1408-68
https://journals.tubitak.gov.tr/medical/vol45/iss5/28/
http://hdl.handle.net/11452/34238
ISSN: 1300-0144
Koleksiyonlarda Görünür:Scopus
TrDizin
Web of Science

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